HERV-K activation is strictly required to sustain CD133+ melanoma cells with stemness features
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چکیده
منابع مشابه
HERV-K activation is strictly required to sustain CD133+ melanoma cells with stemness features
BACKGROUND Melanoma is a heterogeneous tumor in which phenotype-switching and CD133 marker have been associated with metastasis promotion and chemotherapy resistance. CD133 positive (CD133+) subpopulation has also been suggested as putative cancer stem cell (CSC) of melanoma tumor. Human endogenous retrovirus type K (HERV-K) has been described to be aberrantly activated during melanoma progress...
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Background and Objective: Melanoma is the most deadly type of skin cancer that has a high potency and rapid metastasis to other organs. It appears that cancer stem cells (CSCs) are responsible for invasion and metastasis. The aim of this study was to investigate the expression of cancer stem cells candidate markers and their association with stemness features in mel...
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ژورنال
عنوان ژورنال: Journal of Experimental & Clinical Cancer Research
سال: 2017
ISSN: 1756-9966
DOI: 10.1186/s13046-016-0485-x